I cry when I watch movies, almost all movies. When the movie is very very very sad, I often wish I had black tissue to match the color of my soul.
When you're sick and you need a tissue, it's nice to know you can snuggle in and feel at home.
Pulling something out of your nose to wipe my nose is a little too meta, but I've got a cold and I need a tissue no matter what.
Sometimes you're just too sick to stand up and fetch yourself a tissue.
Kleenex boxes are not so cute, just be careful to not blow your nose on Eeyore.