I cry when I watch movies, almost all movies. When the movie is very very very sad, I often wish I had black tissue to match the color of my soul.
When you're sick and you need a tissue, it's nice to know you can snuggle in and feel at home.
Pulling something out of your nose to wipe my nose is a little too meta, but I've got a cold and I need a tissue no matter what.
Kleenex boxes are not so cute, just be careful to not blow your nose on Eeyore.
Sometimes you're just too sick to stand up and fetch yourself a tissue.