It's just like bingo. (Except it has six squares across and not five, because this is Fringe, and Fringe is weird.)
It's easy to play! While watching any new or repeat episode, cover the squares as things happen in the episode.
You can use a coin (silver half dollars work best) or a Necco wafer to cover the squares.
If you get a row of 6 up or down (or diagonally), yell out "I LOVE FRINGE!"
(Hint: The photos are just illustrations. When in doubt, go by the description on the square! Also, make sure you match the glyphs!)